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phenobarbital will lessen the level or result of ramelteon by affecting hepatic enzyme CYP2C9/10 metabolism. Minimal/Significance Unknown.phenobarbital will lessen the extent or outcome of brexpiprazole by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep track of Closely. Double brexpiprazole dose in excess of one-2 week

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